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    Gene Expression and Cell Cycle Regulation

    Ellen R. Download preview PDF. Skip to main content. Advertisement Hide. Synchronous DNA synthesis and mitosis in multinucleate cells with one chromosome in each nucleus. Authors Authors and affiliations S. Ghosh N. This process is experimental and the keywords may be updated as the learning algorithm improves. This is a preview of subscription content, log in to check access. Chromosoma — Google Scholar.

    Hepler PK Membranes in the mitotic apparatus of barley cells. J Cell Biol — Google Scholar. Requirements for nuclear DNA synthesis.

    Exp Cell Res — Google Scholar. In general, mitosis is preceded by the S stage of interphase and is often accompanied or followed by cytokinesis, which divides the cytoplasm, organelles and cell membrane into two new cells containing roughly equal shares of these cellular components. Mitosis and cytokinesis together define the mitotic M phase of an animal cell cycle—the division of the mother cell into two daughter cells genetically identical to each other. Cell division is the process by which a parent cell divides into two or more daughter cells.

    Cell division usually occurs as part of a larger cell cycle. In eukaryotes, there are two distinct types of cell division: a vegetative division, whereby each daughter cell is genetically identical to the parent cell mitosis , and a reproductive cell division, whereby the number of chromosomes in the daughter cells is reduced by half to produce haploid gametes meiosis. Meiosis results in four haploid daughter cells by undergoing one round of DNA replication followed by two divisions. Homologous chromosomes are separated in the first division, and sister chromatids are separated in the second division.

    Both of these cell division cycles are used in the process of sexual reproduction at some point in their life cycle. Both are believed to be present in the last eukaryotic common ancestor. Nocodazole is an antineoplastic agent which exerts its effect in cells by interfering with the polymerization of microtubules.

    Microtubules are one type of fibre which constitutes the cytoskeleton, and the dynamic microtubule network has several important roles in the cell, including vesicular transport, forming the mitotic spindle and in cytokinesis. Several drugs including vincristine and colcemid are similar to nocodazole in that they interfere with microtubule polymerization. In embryology, cleavage is the division of cells in the early embryo. The process follows fertilization, with the transfer being triggered by the activation of a cyclin-dependent kinase complex.

    The zygotes of many species undergo rapid cell cycles with no significant overall growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula. Daniel Mazia was an American cell biologist, best known for his research with Katsuma Dan that isolated the cell structures responsible for mitosis.

    Aurora B kinase is a protein that functions in the attachment of the mitotic spindle to the centromere.

    Cell Reproduction - 1st Edition

    He serves as the first editor-in-chief of the open-access journal Open Biology published by the Royal Society. Citron Rho-interacting kinase is an enzyme that in humans is encoded by the CIT gene. His research field is the visualization of dynamic processes within living cells using light microscopy. Currently he is a researcher at the Marine Biological Laboratory.

    Cell Division and the Cell Cycle

    Ray Rappaport was an American cell biologist. He did pioneering research using physical manipulations of cells to understand the mechanisms of cytokinesis, the process by which a cell's cytoplasm is divided in two. Joan V. Ruderman is an American molecular and cell biologist. She has researched cell division and embryo development, and more recently the effects of, and the public understanding of, environmental estrogens and other endocrine disruptors. Amy S. Gladfelter is a quantitative cell biologist and Associate Professor of Biology at the University of North Carolina at Chapel Hill, where she mainly investigates cell cycle-control and the septin cytoskeleton.

    During her work, she has discovered that multinucleated cells can undergo the cell cycle asynchronously. Additionally, she has been able to determine how septin filaments assemble and the impacts their malfunction have. She has trained and mentored many undergraduate and graduate students, as well as postdoctoral fellows. Gilgut and Ray Ethan Torrey Professor Emeritus in the Biology Department of the University of Massachusetts at Amherst who is notable for his work on elucidating the roles of calcium, membranes and the cytoskeleton in plant cell development and cell motility.

    Teru "Tay" Hayashi was a Japanese-American cell biologist and physiologist known for his research on the biochemical mechanisms of muscle contraction. James David Ebert was an American biologist and administrator. Retrieved 1 December